国产av自拍

姓名： 肖富辉 职务： 职称： 研究员 政治面貌： 群众 最高学历学位： 研究生、博士 专业: 遗传学 所属院系: 药国产av自拍 研究方向: 抗衰老与老年病防治 电话: 信箱: [email protected] 个人主页: //www.researchgate.net/profile/Fuhuii-Xiao

个人简介

肖富辉博士，研究员，博士生导师。2016年于中国科国产av自拍大学（中国科国产av自拍昆明动物研究所）获得理学博士学位（硕博连读）。曾先后担任中国科国产av自拍昆明动物研究所助理研究员和副研究员。自2025年起，任宁波大学国产av自拍 研究员。

长期从事人类健康增龄的分子机制研究，采用人群队列多组学分析与细胞及模式动物功能实验相结合的研究策略，旨在揭示影响健康增龄的关键因素，为延缓衰老及预防年龄相关疾病提供科学依据。相关成果以第一/通讯作者（含并列）发表在《Science Advances》、《National Science Review》、《Aging Cell》、《Genome Research》等国际核心刊物。主持国家自然科学基金、中国科国产av自拍“西部青年学者”、云南省基础研究专项、云南省中青年学术和技术带头人后备人才等多项科研和人才项目；参与国家重点研发计划重点专项项目、中科院重点部署项目等。受邀为《Nature Communication》、《Clinical Epigenetics》、《Human Genomics》、《BMC Microbiology》等多个国际知名期刊审稿；兼任中国老年医学学会基础与转化医学分会委员等。

学习和工作经历

2025-至今，宁波大学国产av自拍 ，研究员

2019-2024，中国科国产av自拍昆明动物研究所，副研究员

2016-2018，中国科国产av自拍昆明动物研究所，助理研究员

2010-2016，中国科国产av自拍大学（中国科国产av自拍昆明动物研究所），遗传学，博士

2006-2010，滨州国产av自拍（现为山东航空国产av自拍），生物科学，学士

近年发表的主要论文

1.Xiao FH^#, Wang HT^#, Chen XQ, Ge MX, Yan D, Yang XL, Yang LQ, Lin R, Guo RH, Zhang W, Tang N, He Y, Zhou J, Cai WW*, Kong QP*. Hypermethylation in H3K9me3 regions characterizes the centenarian methylomes in healthy aging. National Science Review, 2023, 10:nwad067.

2.Xiao FH^#, Yu Q^#, Deng ZL^#, Yang K, Ye Y, Ge MX, Yan D, Wang HT, Chen XQ, Yang LQ, Yang BY, Lin R, Zhang W, Yang XL, Dong L, He YH, Zhou J, Cai WW*, Li J*, Kong QP*. ETS1 acts as a regulator of human healthy aging via decreasing ribosomal activity. Science Advances, 2022, 8:eabf2017.

3.Wang HT, Zhao L, Yang LQ, Ge MX, Yang XL, Gao ZL, Cun YP*, Xiao FH*, Kong QP*. Scrutiny of genome-wide somatic mutation profiles in centenarians identifies the key genomic regions for human longevity. Aging Cell, 2024, 23:e13916.

4.Wang HT^#, Xiao FH^#,*, Gao ZL, Guo LY, Yang LQ, Li GH, Kong QP*. Methylation entropy landscape of Chinese long-lived individuals reveals lower epigenetic noise related to human healthy aging. Aging Cell, 2024, 23:e14163.

5.Xiao FH^#, Chen XQ^#, Yu Q^#, Ye Y^#, Liu YW, Yan D, Yang LQ, Chen G, Lin R, Yang L, Liao X, Zhang W, Zhang W, Tang NLS, Wang XF, Zhou J*, Cai WW*, He YH*, Kong QP*. Transcriptome evidence reveals enhanced autophagy-lysosomal function in centenarians. Genome Research, 2018, 28:1601-1610. (Cover Story)

6.Xiao FH, Chen XQ, He YH, Kong QP. Accelerated DNA methylation changes in middle-aged men define sexual dimorphism in human lifespans. Clinical Epigenetics, 2018, 10:133.

7.Chen XQ, Zhang F, Su QC, Zeng C, Xiao FH*, Peng Y*. Methylome and transcriptome analyses reveal insights into the epigenetic basis for the good survival of hypomethylated ER-positive breast cancer subtype. Clinical Epigenetics, 2020, 12:16.

8.Xiao FH, Wang HT, Kong QP. Dynamic DNA methylation during aging: a "prophet" of age-related outcomes. Frontiers in Genetics, 2019, 10:107.

9.Xiao FH, Kong QP, Perry B, He YH. Progress on the role of DNA methylation in aging and longevity. Briefings in Functional Genomics, 2016, 15:454-459.

10.Xiao FH^#, He YH^#, Li QG, Wu H, Luo LH*, Kong QP*. A genome-wide scan reveals important roles of DNA methylation in human longevity by regulating age-related disease genes. PLoS One, 2015, 10:e0120388.

11.Chen XQ, Zhang F, Xiao FH*, Peng Y*. Deciphering the nexus between the tumor immune microenvironment and DNA methylation in subgrouping estrogen receptor-positive breast cancer. Breast Cancer, 2021, 28:1252-1260.

12.Aging Biomarker Consortium^#, Bao H^#, Cao J^#, Chen M^#, Chen M^#, Chen W^#, Chen X^#, Chen Y^#, Chen Y^#, Chen Y^#, Chen Z^#, Chhetri JK^#, Feng J^#, Guo J^#, Guo M^#, He C^#, Jia Y^#, Jiang H^#, Jing Y^#, Li D^#, Li J^#, Li J^#, Liang Q^#, Liang R^#, Liu F^#, Liu X^#, Liu Z^#, Luo J^#, Lv J^#, Ma JY^#, Mao K^#, Nie J^#, Qiao X^#, Sun X^#, Tang X^#, Wang J^#, Wang Q^#, Wang S^#, Wang X^#, Wang Y^#, Wu R^#, Xia K^#, Xiao FH^#, Xu L^#, Xu Y^#, Yan H^#, Yang L^#, Yang R^#, Ying Y^#, Zhang L^#, Zhang W^#, Zhang W^#, Zhang X^#, Zhang Z^#, Zhou M^#, Zhou R^#, Zhu Q^#, Zhu Z^#, Cao F*, Cao Z*, Chan P*, Chen C*, Chen G*, Chen HZ*, Chen J*, Ci W*, Ding BS*, Ding Q*, Gao F*, Han JD*, Huang K*, Ju Z*, Kong Q*, Li J*, Li J*, Li X*, Liu B*, Liu L*, Liu Q*, Liu Q*, Liu X*, Liu Y*, Luo X*, Ma S*, Ma X*, Mao Z*, Nie J*, Peng Y*, Qu J*, Ren J*, Ren R*, Song M*, Songyang Z*, Sun YE*, Sun Y*, Tian M*, Wang SS*, Wang S*, Wang X*, Wang X*, Wang YJ*, Wang Y*, Wong C*, Xiang P*, Xiao Y*, Xie Z*, Xu D*, Ye J*, Yue R*, Zhang C*, Zhang H*, Zhang L*, Zhang W*, Zhang Y*, Zhang YW*, Zhang Z*, Zhao T*, Zhao Y*, Zhu D*, Zou W*, Pei G*, Liu GH*. Biomarkers of aging. Science China-Life Sciences, 2023, 66:893-1066.

13.Cai Y^#, Song W^#, Li J^#, Jing Y^#, Liang C^#, Zhang L^#, Zhang X^#, Zhang W^#, Liu B^#, An Y^#, Li J^#, Tang B^#, Pei S^#, Wu X^#, Liu Y^#, Zhuang CL^#, Ying Y^#, Dou X^#, Chen Y^#, Xiao FH^#, Li D^#, Yang R^#, Zhao Y^#, Wang Y^#, Wang L^#, Li Y^#, Ma S*, Wang S*, Song X*, Ren J*, Zhang L*, Wang J*, Zhang W*, Xie Z*, Qu J*, Wang J*, Xiao Y*, Tian Y*, Wang G*, Hu P*, Ye J*, Sun Y*, Mao Z*, Kong QP*, Liu Q*, Zou W*, Tian XL*, Xiao ZX*, Liu Y*, Liu JP*, Song M*, Han JD*, Liu GH*. The landscape of aging. Science China-Life Sciences, 2022, 65:2354-2454.

14.Tang JX*, Xiao FH*. Editorial: The regulation of proteostasis in aging. Frontiers in Cell and Developmental Biology, 2023, 11:1221510.

15.Chen XQ^#,*, Zhang X^#, Pan DG^#, Li GY, Hu RX, Wu T, Shen T, Cai XY, Cheng XS, Qin J, Xiao FH*, Li YF*. Identification of lncRNA-mRNA network linking ferroptosis and immune infiltration to colon adenocarcinoma suppression. Heliyon, 2024, 10:e33738.

16.Chen XQ^#,*, Yang Q^#, Chen WM^#, Chen ZW, Guo GH, Zhang X, Sun XM, Shen T, Xiao FH*, Li YF*. Dual role of lysosome in cancer development and progression. Frontiers in Bioscience-Landmark, 2024, 29:393.

17.Yin FQ, Xiao FH*, Kong QP*. Factors involved in human healthy aging: insights from longevity individuals. Frontiers of Medicine, 2024, Accepted.

18.肖富辉，孔庆鹏*。人类健康增龄的发生机制——来自长寿人群的研究证据。中国医学前沿杂志（电子版），2024，16：23-28。（专家述评）

近年主持/参与的项目

1.国家自然科学基金面上项目，2024.01至2027.12，82371580，主持

2.国家自然科学基金面上项目，2021.01至2024.12，82071595，主持

3.国家自然科学基金青年基金项目，2018.01至2020.12，81701394，主持

4.云南省基础研究专项优秀青年项目，2024.03至2027.02，202401AW070011，主持

5.云南省基础研究专项重点项目，2022.06至2025.05，202201AS070080，主持

6.云南省高层次科技人才及创新团队选拔专项，中青年学术和技术带头人后备人才，2023.01至2027.12，202305AC160029，主持

7.云南省基础研究专项面上项目，2018.06至2021.05，2018FB121，主持

8.中国科国产av自拍“西部青年学者”项目，2022.01至2024.12，主持

9.中国科国产av自拍“西部青年学者”B类项目，2017.01至2020.12，主持

已获授权的发明专利

略

著作编写

略

学术兼职

中国老年医学学会基础与转化医学分会委员